Primary Psychiatry - Non-CME Article RSS Feed

A Severe Case of Bupropion Hydrochloride Extended-Release Monotherapy-Associated Visual Hallucinations and Delirium in a Female Patient with Major Depressive Disorder

Chi-Un Pae, MD, PhD — Thu, 2 Sep 2010 16:11:06 -05

Rapid Improvement in Bipolar II Depression Induced by Low-Dose Lamotrigine Augmentation: Two Case Reports

Omer Akil Ozer, MD, Okan Ekinci, MD and Ali Caykoylu, MD — Thu, 2 Sep 2010 15:59:17 -05

Rivastigmine and Concomitant Memantine in Alzheimer’s Disease: Safety and Tolerability

Beth Safirstein, MD, Xiangyi Meng, PhD, and Jason T. Olin, MD, PhD — Thu, 2 Sep 2010 15:10:16 -05

Rivastigmine is a cholinesterase inhibitor (ChEI) approved in the United States for the symptomatic treatment of mild-to-moderate Alzheimer’s disease (AD) and Parkinson’s disease dementia. As with other orally administered ChEIs, rivastigmine may be associated with gastrointestinal (GI) side effects.

Cerebrospinal Fluid Tau and Amyloid b Proteins Do Not Correlate With Cognitive Functioning in Cognitively Impaired Memory Clinic Patients

Thu, 2 Sep 2010 14:06:31 -05

Cerebrospinal fluid (CSF) biomarkers amyloid ß42 (Aß42), phosphorylated tau181 (p-tau) and total tau (t-tau) concentrations are altered in Alzheimer’s disease (AD) patients compared to controls. In other types of dementia and also in part of the patients with mild cognitive impairment (MCI), changes in these biomarker concentrations, although less specific, have been reported.

Use of SSRIs May Impact Bone Density in Adolescent and Young Women With Anorexia Nervosa

Thu, 2 Sep 2010 13:09:51 -05

Anorexia nervosa (AN), an eating disorder characterized by severe undernutrition, is known to have a significant negative impact on bone health, which has been attributed to the associated hypogonadism, low insulin-like growth factor-1 levels, relative hypercortisolemia, alterations in other hormones such as adiponectin, leptin, and peptide YY,and changes in body mass index and lean body mass. However, these hormonal and body composition alterations do not account for all the variability in bone mineral density (BMD) in AN, and other determinants of low BMD remain to be determined.

Cerebral Ventricular Asymmetry and Ventriculomegaly Interact to Increase Risk for Schizophrenia: A Case Report and Recommendation for Routine Fetal Sonography

Thu, 2 Sep 2010 11:36:22 -05

Increasingly, antepartum ultrasonographic examination of the fetal neural axis occurs routinely during pregnancy. Mild cerebral ventriculomegaly is usually defined operationally as the measured transverse diameter of the atria of the lateral ventricles in the fetus that is >10 mm and <15 mm; the mean width is 7.6 mm+0.6 and remains stable from week 14–38 of gestation.

Clinical Response and Symptomatic Remission in Children Treated With Lisdexamfetamine Dimesylate for Attention-Deficit/Hyperactivity Disorder

Thu, 2 Sep 2010 10:29:49 -05

Attention-deficit/hyperactivity disorder (ADHD) is among the most commonly diagnosed and treated neurobehavioral disorders in children, with studies indicating that it affects ~4% to 12% of school-aged youths.

The Clinical Future of Repetitive Transcranial Magnetic Stimulation and Depression: Separating Hope From Hype

Stefano Pallanti, MD, PhD, Thomas E. Schlaepfer, MD, and Sarah H. Lisanby, MD — Thu, 2 Sep 2010 09:25:31 -05

One of the key messages of the Sequenced Treatment Alternatives to Relieve Depression study1 was that only one third of patients with a diagnosis of major depressive disorder (MDD) achieve remission after the first treatment with an antidepressant. Management of most patients after one or more failed trials moves beyond the currently available evidence base and therefore represents a significant clinical challenge.

Depression: There Is No Upside

Andrew A. Nierenberg, MD — Thu, 2 Sep 2010 09:00:33 -05

In February 2010, The New York Times published a remarkable story that was so stunningly off base that my patients who have serious depression actually laughed about it. In this story, the author makes the argument that in some mysterious way, there is an upside to depression. One of my patients, who has severe recurrent depressions, decided to write a rejoinder that is included below, with permission.

Psychiatric Dispatches: News from the Alzheimer’s Association International Conference on Alzheimer’s Disease 2010: September 2010

Wed, 1 Sep 2010 11:45:42 -05